We report a case of primary cutaneous infection by the emerging fungus Aspergillus ustus in an immunosuppressed patient after a domestic accident. Aspergillus ustus is a mold that rarely infects humans; only 15 systemic cases have been reported. We report the first outbreak of invasive infection caused by A . Med Mycol. Jun;45(4) Clustering of invasive Aspergillus ustus eye infections in a tertiary care hospital: a molecular epidemiologic study of an.
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Patient charts from the four cases were reviewed retrospectively and indicated that postoperative signs of fungal endophthalmitis developed in the patients weeks after surgery.
RAPD and phylogenetic analysis qspergillus genetic similarity between isolates from different patients. At the time of his diagnosis and death, patient 2 resided in a room directly adjacent to and above the room of patient 5, albeit 2 years earlier Figure 1.
Journal of Clinical Microbiology. Molecular Typing Molecular typing of A. Aspergillus Fungi described in For example, at the Fred Hutchinson Cancer Research Center in Seattle, the proportion of infections caused by non- fumigatus Aspergillus species increased during the latter s.
However, in recent years, IA has been increasingly caused by non- fumigatus Aspergillus species. The first occurred from July to October 3 probable lung infections: The isolates recovered from the 5 HSCT were genetically similar.
Antifungal drug susceptibility testing of clinical aspergiillus demonstrated relatively high MICs to all antifungal drugs tested Table 2. We report the first outbreak of invasive infection caused by A.
Aspergillus ustus | Aspergillus & Aspergillosis Website
Arunmozhi Balajee and Jennifer Gribskov for their assistance in antifungal drug susceptibility testing. Rheumatic heart disease, prosthetic valve replacement. More studies will be necessary to determine the clinical consequence of antifungal resistance in A. Molecular typing by using randomly amplified polymorphic DNA RAPD and antifungal drug susceptibility testing were performed on clinical and environmental isolates recovered from our hospital from to Sterigmatocystis usta Bainier Aspergillus minutus Abbott Aspergillus ustus var.
Environmental Sampling Based on the spot map, environmental air sampling of patient hospital rooms was performed, and environmental isolates were obtained.
Aspergillus ustus, antifungal drug resistance, emerging pathogen, outbreak, transplantation, research. Most of our patients received mold-active azole drugs before diagnosis as either prophylaxis or therapy for a previous infection with A. Primary cutaneous infection by Aspergillus ustus in a year-old liver transplant recipient. Pavie J, Lacroix C, Hermose DG Breakthrough disseminated Aspergillus ustus infection in allogeneic hematopoietic stem cell transplant recipients receiving voriconazole and caspofungin prophylaxis.
Similarly, the isolate from patient 1 was genetically most similar to that of patient 4; patients 1 and 4 resided in adjacent rooms, also separated by a period of 2 years. N Engl J Med. Masson, p, Ustic acid has since been shown to occur in other fungi, notably closely related Aspergilli such as A. Its growth on edition paper is less fast and is very weak on cotton fabric.
Aspergillus ustus – Wikipedia
Of note, construction of a new surgery pavilion occurred outside our hospital building beginning in July and ending in December Like other members of the genus Aspergillusthe A. The Journal of Antibiotics.
However, the environmental niche of this fungus is not known. The isolate from patient 3 was not viable on subculturing and, as such, was usgus available for molecular analysis. Dr Panackal received grant support from the John P. Organisms were identified to the species level by using standard morphologic criteria for A.
Many reported cases have been either primary cutaneous disease or disseminated infection, however, we cannot draw firm conclusions regarding the types of infections this organism causes because of the high likelihood of reporting bias.
It is moss-green on all studied materials. In the absence of substantial air disturbances, A.