na Agência de Proteção Ambiental Alemã (UBA – Umweltbundesamt) sob sua Avaliação da genotoxicidade/mutagenicidade das amostras teste pela. ambiental, devido a ineficácia de medicamentos alopáticos para o controle de parasitoses como . genotoxicidade de substâncias ambientais. 4,16, Gerente do Setor de Toxicologia e Genotoxicidade, CETESB Genotoxicidade ambiental Estrategias para a avaliacao da genotoxicidade de sedimentos.

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Genotoxicidade Ambiental Biomarkers Environmental tobbaco smoke Genotoxicity. A simple method for determination of serum catalase activity and revision of reference range. Show full item record Give your opinion. Genotoxicity and oxidative stress in gasoline station attendants. Please use this identifier to cite or link to this item: In lower concentrations we could observe a high non-linear risk of leukemia, probably due to a greater benzene metabolism and a higher production of its toxic metabolites.

Single-cell gel electrophoresis combined with lesion-specific enzymes to measure oxidative damage to DNA.

Data obtained with both methods were compared and reproducibility of the methylation-sensitive modified version of the comet assay determined. Human biomonitoring ; Biomarkers of exposure ; Environment-wide association studies Source: Throughout the years, this biomarker has undergone several adaptations in their protocol in order to increase its sensitivity and the possible outcomes. Monitoring of gas station attendants exposure to benzene, toluene, xylene BTX using three-color chromosome painting.

Homes, child day-care centres, primary schools and elderly care centres.

Deborah A. Roubicek – Google Scholar Citations

All Author Title Subject. No association related to the other polymorphisms was detected. Isabele Campos Costa-Amaral E-mail: Mechanism of action of benzene toxicity: Penicillium and Cladosporium were the most frequently occurring fungi. Assessment and determinants of airborne bacterial and fungal concentrations in different indoor environments: Services on Demand Journal. For each building, one outdoor representative location were identified and simultaneously studied.


Some industrial chemicals and dyestuffs. Metabolic polymorphisms and clinical findings related to benzene poisoning detected in exposed brazilian gas-station workers. Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

Powered By Stacks 3. The inter-laboratory variation was the prominent contributor to the overall variation. Biomarkers of exposure ; Biomonitoring equivalents ; Environment-wide association studies Source: Results obtained contribute to knowledge on the feasibility of this version of the comet assay and its possible usage in human biomonitoring studies as an epigenetic biomarker. By including an additional step of DNA digestion with lesion-specific endonucleases, the comet assay can provide information regarding the type of DNA damage detected in cells.

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Mutagênese ambiental/nanotoxicologia/ecotoxicologia/genotoxicidade

Annu Rev Pharmacol Toxicol. Please use this identifier to cite or link genotoxiciidade this item: The use of comet assay to assess global DNA methylation in human biomonitoring studies. Show full item record Give your opinion. DNA damage was assessed by the comet assay in blood ambiengal and by micronucleus MN analysis in buccal cells. Biomarkers of exposure ; Biomonitoring equivalents ; Environment-wide association studies.

Flexible meta-regression to assess the shape of the benzene-leukemia exposure-response curve.

genktoxicidade Assay for differentiation of glutathione S-transferases. Portuguese legislation prohibits smoking in most indoor public spaces. In contrast, there was no difference between the levels of FPG sensitive sites in PBMC samples from healthy donors in the different centres 0. Biomonitoring of the workplace and environment. Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ-C.


Int J Occup Environ Med. Bull Environ Contam Toxicol. Item request cannot be made.

In this context, the aim of this work was to make use of this version of the comet assay to characterize global DNA methylation in approximately 50 human samples. The impact of BTEX emissions from gas stations into the atmosphere.

Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment ; DiMoPEx-project is designed to determine the impacts of environmental exposure on human health Authors: Programme and Abstract Book Authors: Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories. Rio de Janeiro, RJ, Brasil. Environmental assessment of BTEX benzene, toluene, ethylbenzene, xylenes and biomarkers of genotoxicity in gas stations workers.

Your Filters Filter by: The study aim was to assess variation in DNA damage in PBMC samples that were collected in the same way and processed using the same blood isolation procedure.

Until now the influence of risk factors resulting from exposure to biological agents in indoor air has been far less studied than outdoor pollution; therefore the uncertainty of health risks, and how to effectively prevent these, remains.

Air samples were collected in 68 homes, 9 child day-care centres, 20 primary schools and 22 elderly care centres, in a total of rooms with a microbiological air sampler and using tryptic soy agar and malt extract agar culture media for bacteria and fungi growth, respectively.